Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Glycocalyx / extracellular matrix signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| HSPG2 | participates_in | gene | 0.39 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Glial Glycocalyx Remodeling Therapy | 0.415 | neurodegeneration | 4R-tau strain-specific spreading pattern |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic sc [PMID:38448448] | Yang ZR, Suo H, Fan JW, Lv N, Du K, Ma T | Nat Commun | 2024 | 1 |
| The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p [PMID:39149513] | Samaržija I, Lukiyanchuk V, Lončarić M, | Front Cell Dev Biol | 2024 | 1 |
| APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. [PMID:34433968] | Tsiantoulas D, Eslami M, Obermayer G, Cl | Nature | 2021 | 1 |
| Interactions between the products of the Herpes simplex genome and Alzheimer's d [PMID:18164103] | Carter CJ | Neurochem Int | 2008 | 1 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| The interaction of endorepellin and neurexin triggers neuroepithelial autophagy [PMID:38702277] | Lu L, Bai M, Zheng Y, Wang X, Chen Z, Pe | Science bulletin | 2024 | 0 |
| Diverse and multifunctional roles for perlecan (HSPG2) in repair of the interver [PMID:39081381] | Melrose J, Guilak F | JOR spine | 2024 | 0 |
| Spatial transcriptomics reveal markers of histopathological changes in Duchenne [PMID:37582915] | Heezen LGM, Abdelaal T, van Putten M, Aa | Nature communications | 2023 | 0 |
| Effects of different types of land-use on taxonomic and functional diversity of [PMID:33847890] | ["Liu Z", "Li Z", "Castro D", "Tan X", " | Environmental science and poll | 2021 | 0 |
| [Correlation of fibroblast growth factor 23 with adverse prognosis of chronic k [PMID:29886473] | ["Liu H", "Liu H"] | Zhong nan da xue xue bao. Yi x | 2018 | 0 |
| The link between dissociation and both suicide attempts and non-suicidal self-in [PMID:28196773] | ["Calati R", "Bensassi I", "Courtet P"] | Psychiatry research | 2017 | 0 |
| Alignment-free sequence comparison based on next-generation sequencing reads. [PMID:23383994] | ["Song K", "Ren J", "Zhai Z", "Liu X", " | Journal of computational biolo | 2013 | 0 |
| Influenza virus h5 DNA vaccination is immunogenic by intramuscular and intraderm [PMID:22956656] | ["Ledgerwood J", "Hu Z", "Gordon I", "Ya | Clinical and vaccine immunolog | 2012 | 0 |